绿帽社

December 14, 2024
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New study determines how ultraviolet radiation hurts our skin

How much sun is too much? 绿帽社 U. researchers develop damage scale

Some sunlight can be healthy, but too much ultraviolet radiation can cause long-term harm to your skin. Some sunlight can be healthy, but too much ultraviolet radiation can cause long-term harm to your skin.
Some sunlight can be healthy, but too much ultraviolet radiation can cause long-term harm to your skin.

Even if you did your best to prevent it, chances are you鈥檝e suffered from some kind of sunburn this summer. Covering yourself in sunscreen and limiting your time outdoors can protect us only so much.

But what kind of ultraviolet radiation is the worst for our skin? And how exactly does the sun damage it?

Those two questions are at the heart of a new study by Zachary W. Lipsky, a biomedical engineering PhD candidate at 绿帽社鈥檚 Thomas J. Watson School of Engineering and Applied Science. The study, overseen by Associate Professor Guy K. German, was accepted in early August to the Journal of the Mechanical Behavior of Biomedical Materials.

Ultraviolet radiation 鈥 which the human eye can鈥檛 perceive 鈥 is broken down into four categories depending on wavelength and photon energy:

  • Ultraviolet A is the longest wavelength (315 to 400 nanometers) and is not absorbed by the Earth鈥檚 ozone layer.
  • Ultraviolet B is the medium range nanometers (280 to 315 nanometers) and is mostly absorbed before it reaches us. The human body produces helpful Vitamin D with 5 to 15 minutes of casual solar exposure to UVB, but more time outside when unprotected from the sun can be harmful.
  • Ultraviolet C (200 to 280 nanometers) is completely absorbed by the ozone layer, although it is present in welding operations and can be used as a germicide.
  • Vacuum ultraviolet (100 to 200 nanometers) occurs on Earth only under laboratory conditions and is very close to the X-ray spectrum.

Previous studies have documented how each type of UV radiation penetrates to different depths into the skin and that prolonged exposure can lead to skin cancer, but exactly how it damages human skin in other ways has received less attention. Researchers from the cosmetics industry have debated for years whether UVA is worse than UVB for causing photodamage, which leads to the early onset of wrinkles and increased tissue fragility.

The 绿帽社 study used samples of female breast skin 鈥 chosen because it is typically exposed only to low levels of sunlight 鈥 that were subjected to various wavelengths of UV radiation. What Lipsky and German found is that no UV range is more harmful than another 鈥 rather, the damage scales with the amount of UV energy that the skin absorbs.

A more significant discovery, however, is the mechanism for how exactly UV damages skin. The study shows that UV weakens the bonds between cells in the stratum corneum 鈥 the top layer of skin 鈥 by affecting proteins in corneodesmosomes that help the cells to adhere together. That鈥檚 why sunburn leads to skin peeling.

鈥淲hat we noticed when we applied more and more UV radiation is that the dispersion of these corneodesmosomes was increasing,鈥 Lipsky said. 鈥淭hey鈥檙e supposed to be these nice little distinct points surrounding cells, but with more irradiation, they essentially look exploded, moving away from their position. We conclude that because of the disruption of these corneodesmosomes, it damages the skin鈥檚 structural integrity.鈥

German compared the UV damage to a common problem for homeowners: 鈥淢y neighbor is always on his roof because he has six or seven chimneys. He鈥檚 always up there repointing them, and if he doesn鈥檛, the chimney鈥檚 going to fall down. The analogy here is that the UV is chipping away at this 鈥榤ortar鈥 in the skin, and eventually that 鈥榗himney鈥 will fall down. The bricks are still fine, but the mortar is rotting away.鈥

Building on the findings of this study, Lipsky and German are doing further research about how UV radiation affects deeper layers of the skin.

鈥淭he cosmetics industry is a huge multibillion-dollar business, and they鈥檙e all trying different things to add to their sunscreens to make them better at protecting skin,鈥 German said. 鈥淯p until this point, however, there have been a lot of studies about skin damage, but none that properly look at how UV affects the mechanical integrity of skin.鈥

As those experiments continue, Lipsky said the most important takeaway for now is that skin protection is important no matter what season of the year it is: 鈥淲e鈥檙e trying to push the message to use sunscreen not just for preventing skin cancer, but also to keep the integrity of your skin so you don鈥檛 get infections or other problems.

鈥淭he stratum corneum is the first barrier to the outside environment, so we need to protect it against all these different bacteria and nasty stuff that can get into our bodies.鈥

The study will be published in print in December by the Journal of the Mechanical Behavior of Biomedical Materials. It was supported by German鈥檚 National Science Foundation CAREER Award (#).